Acetaminophen: Most common cause of acute liver failure in US
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Demographic Information and Clinical and Laboratory Findings in Acetaminophen Poisoning Cases in Rasht, Iran, in 2008
Background: Acetaminophen is widely used as an analgesic and antipyretic drug and it is a frequent cause of acute drug poisoning.This study was carried out to investigate the demographic information and clinical and laboratory findings in acetaminophen poisoning patients referred to “17 Shahrivar” and “Razi” educational hospitals, Rasht. Methods: In this retrospective cross-sectional study, 1...
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Acute liver failure (ALF), the manifestation of severe hepatocellular injury in the absence of pre-existing liver disease is a catastrophic and frequently fatal disorder. Though the injury is potentially reversible, the clinical course often culminates in multiple organ failure which is associated with a poor prognosis. The incidence is between 1 and 6 per million population per year [1]. Howev...
متن کاملHepatotoxicity of paracetamol and related fatalities.
Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 it is available over-the-counter as a single formulation or in combination with other substances and, as indicated by the World Health Organization, it can be used in all the three steps of pain intensity. Paracetamol toxicity is one of the most common causes of poisoning worldwide. ...
متن کاملEryngium Bungei Boiss Extract Has Hepatoprotective Effect Against Liver Damage Induced by Acetaminophen in Rats: Novel Antioxidant and Anti-Inflammatory Effects
Background: Acetaminophen-induced toxicity is a common cause of acute liver failure. This study investigated the hepatoprotective effects of Eryngium bungei Boiss (EB) extract against the hepatotoxicity in rats. Methods: Thirty adult male rats were randomly assigned to five groups, with free access to water and food. They were treated as follows: Group 1 (negative controls): distilled water ...
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Drug-induced liver injury (DILI) has been linked to more than 1,000 medications and remains the most common cause of acute liver failure in the United States. Here, we review the most current literature regarding treatment and make recommendations for the management of this relatively common disease. Since treatment of DILI remains largely elusive, recent studies have attempted to define new ma...
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تاریخ انتشار 2014